What is the rationale to launch this combination ?
Inhibiting bacterial growth by altering cell wall synthesis at two levels i.e. by binding to PBPs (ceftriaxone) and simultaneously allowing vancomycin to bind to NAM/NAG subunits to prevent polymerization causes a double blow wherein further construction of bacterial cell wall is altered and antibiotics penetrability is increased and bacterial integrity is lost, thus making Vancoplus susceptible even to vancomycin resistant pathogens.
Are both Vancomycin & Ceftriaxone physically compatible?
Yes it is made possible through unique CVMC (Chemical Vector Mediated Compatibility) technology.
Can VANCOPLUS cross Blood Brain Barrier ?
Yes it can effectively cross BBB and highly tolerable and shows excellent role in Meningitis,Brain Abscess and Shunt infections.
What is the spectrum of activity of Vancoplus?
Gram-Positive aerobes: Staphylococci, including Staphylococcus aureus and Staphylococcus epidermidis (also heterogeneous methicillin-resistant strains), Streptococcus pneumoniae, Streptococcus bovis, Streptococcus pyogenes, Viridans group streptococci, Diphtheroids, Enterococci (e.g., Enterococcus faecalis).
Gram-Positive anaerobes: Actinomyces species, Lactobacillus species, Peptococcus niger
Gram-negative aerobes : Enterobacter aerogenes, Enterobacter cloacae, Haemophilus influenzae, Haemophilus parainfluenzae, Moraxella catarrhalis, Escherichia coli, Proteus mirabilis, Proteus vulgaris, Providencia rettgeri, Providencia stuartii, Morganella morganii, Neisseria gonorrhoeae, Neisseria meningitidis, Serratia marcescens.
Gram-negative anaerobic microorganisms: Clostridium species and Peptostreptococcus species
Why VANCO PLUS should always be given slow I V ?
Vancoplus must be administered in a dilute solution slowly, over at least 60 minutes . This is due to the high incidence of pain and thrombophlebitis and to avoid an infusion reaction known as the red man syndrome or red neck syndrome.
Is any dosage adjustment is required in Renal Impairment ?
Cetriaxone is excreted via both biliary and renal excretion. Therefore,patients with renal failure normally require no adjustment in dosage of ceftriaxone are administered but concentration of drug in serum should be monitored periodically. If evidence of accumulation exists, dosage should be decreased accordingly. Dosage adjustment with Vancomycin must be made in patients with impaired renal function. In the elderly greater dosage reductions than expected may be necessary because of decreased renal function.
For how many days we can use VANCOPLUS vials after reconstitution?
After reconstitution Vancoplus is stable for 24 hrs. at 2-8 temp.
What is the shelf life of VANCOPLUS ?
In which year this product was invented?
In year 2005